ea0011p512 | Endocrine tumours and neoplasia | ECE2006
Mytakidis N
, Vassiliou E
, Liakos V
, Papagrigoriou L
, Hadzimarkou F
, Kostoglou-Athanasiou I
, Koutsodontis G
, Ladopoulou A
, Bei T
, Yannoukakos D
, Kaldrymidis P
Medullary Thyroid Carcinoma (MTC) is a rare cancer that arises from the thyroid C-cells and occurs as sporadic in 75% of the cases. In 25% of MTC cases, mutations of the RET proto-oncogene are responsible for the development of three dominantly inherited neoplastic disorders including multiple endocrine neoplasia (MEN) 2A, MEN 2B and familial medullary thyroid carcinoma (FMTC). Since 28% of MTC cases considered sporadic conceal germline mutations, direct analysis of the ...